TB-500
Thymosin Beta-4 — Systemic Tissue Regeneration
TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide found in high concentrations in blood platelets and wound fluid. It is one of th...
Formula
C212H350N56O78S
Molecular Weight
4963.5 g/mol
Sequence
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala...
What is this compound?
TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide found in high concentrations in blood platelets and wound fluid. It is one of the most studied peptides for its role in actin regulation and tissue repair. Research in animal models highlights its systemic distribution following administration, allowing it to target injured sites throughout the body.
Systemic tissue repair and regeneration
Actin polymerization regulation for cell migration
Reduction of scar tissue formation
Cardiac muscle protection and repair
Enhanced flexibility and reduced inflammation
Hair follicle activation in research models
How it works
TB-500 binds to G-actin and sequesters it, preventing polymerization. This action promotes cell migration and proliferation. It also downregulates inflammatory cytokines and upregulates metalloproteinases involved in extracellular matrix remodeling....
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Areas of investigation
Discovery to present
1970s
Discovery
TB-500 was first identified and characterized in research contexts.
2000s
Research
Preclinical studies expanded across multiple tissue types and disease models.
2010s
Clinical Progress
Early-stage research progressed toward translational and clinical investigation.
2024+
Current Interest
Active research continues with growing scientific interest and expanding publication volume.
Knowledge connections
Explore how TB-500 connects to mechanisms, research goals, related compounds, and scientific references.
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Primary literature
Reference compilation in progress. See research highlights below.
Cardiac studies show cytoprotective effects following myocardial infarction in animal models
Cardiac studies show cytoprotective effects following myocardial infarction in animal models
Corneal and dermal wound-healing research demonstrates accelerated epithelialization
Corneal and dermal wound-healing research demonstrates accelerated epithelialization
Anti-fibrotic properties investigated in pulmonary and hepatic research contexts
Anti-fibrotic properties investigated in pulmonary and hepatic research contexts
TB-500 — Frequently asked
TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide found in high concentrations in blood platelets and wound fluid. It is one of the most studied pepti... TB-500 belongs to the Healing research category and is studied for its thymosin beta-4 — systemic tissue regeneration.
TB-500 binds to G-actin and sequesters it, preventing polymerization. This action promotes cell migration and proliferation. It also downregulates inflammatory cytokines and upregulates metalloproteinases involved in extracellular matrix remodeling.
Systemic tissue repair and regeneration. Actin polymerization regulation for cell migration. Reduction of scar tissue formation. Cardiac muscle protection and repair. Enhanced flexibility and reduced inflammation. Hair follicle activation in research models.
TB-500 has the molecular formula C212H350N56O78S and a molecular weight of 4963.5 g/mol. Its amino acid sequence is Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser. This structural information is important for researchers studying receptor binding and pharmacokinetics.
Cardiac studies show cytoprotective effects following myocardial infarction in animal models Corneal and dermal wound-healing research demonstrates accelerated epithelialization Anti-fibrotic properties investigated in pulmonary and hepatic research contexts These findings are based on preclinical and clinical research. TB-500 is a research compound and these studies do not constitute medical advice.
No. TB-500 is not FDA-approved for any indication. It is a research chemical studied in preclinical and early clinical research. These compounds are not approved for human therapeutic use and should only be studied in appropriate research settings.
TB-500 belongs to the Healing category, which focuses on research-grade peptides studied for their regenerative and healing properties, supporting tissue repair, inflammation modulation, and systemic recovery. You can explore more compounds in this category on the Healing pillar page.
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Research Disclaimer
TB-500 is a research compound. All information is for educational and research purposes only. Not intended for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease.