Weight Loss Research
Optimize Metabolism. Redefine Body Composition.
Compounds studied for their roles in metabolic regulation, growth hormone signaling, and targeted adipose tissue reduction.
17
Research Compounds
31
Scientific References
Monthly
Updated
Research Snapshot
Evidence Summary
Research Areas
Mechanisms
Research Status
Tesamorelin is FDA-approved for HIV lipodystrophy. Other compounds in preclinical and Phase II research stages.
Evidence Base
17
Compounds
31+
References
Related Research
Research Overview
What this field
investigates
What we research
The Weight Loss category examines compounds studied for their roles in metabolic regulation, growth hormone signaling, and targeted adipose tissue reduction — from lipolytic fragments to GHRH analogues.
How compounds are grouped
Compounds are grouped by mechanism: lipolytic peptides (AOD-9604, HGH Fragment 176-191), GHRH/GHRP secretagogues (CJC-1295, Ipamorelin), and FDA-approved visceral fat targets (Tesamorelin). Each addresses fat metabolism through distinct endocrine pathways.
Research considerations
Tesamorelin is FDA-approved for HIV-associated lipodystrophy. Other compounds are research chemicals. Weight loss peptide research involves metabolic, cardiovascular, and endocrine considerations that require medical supervision in clinical contexts.
Research Category
All Compounds
C78H123N23O23S2
AOD-9604
HGH Fragment — Targeted Fat Metabolism
AOD-9604 (Advanced Obesity Drug 9604) is a modified fragment of the C-terminus of human growth hormone (hGH), ...
C152H252N44O42
CJC-1295
Extended-Release GHRH Analogue
CJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH) that has been modified to extend i...
C38H49N9O5
Ipamorelin
The Selective GH Secretagogue
Ipamorelin is a selective pentapeptide growth hormone secretagogue (GHS) and ghrelin receptor agonist. It is n...
C45H55N9O6
GHRP-2
Growth Hormone Releasing Peptide-2
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide and potent ghrelin receptor agonist. It...
C221H366N72O67S
Tesamorelin
FDA-Approved GHRH Analogue for Visceral Fat
Tesamorelin is a synthetic analogue of GHRH approved by the FDA under the brand name Egrifta® for the reductio...
C78H125N23O23S2
HGH Fragment 176-191
The Lipolytic Fragment of Growth Hormone
HGH Fragment 176-191 is a stabilized analogue of the C-terminal fragment of human growth hormone spanning amin...
C46H56N12O6
GHRP-6
Growth Hormone Releasing Peptide-6
GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide and one of the earliest discovered ghre...
C47H58N12O6
Hexarelin
The Potent GH Secretagogue with Cardioprotective Action
Hexarelin (Examorelin) is a synthetic hexapeptide and potent ghrelin receptor agonist developed by Mediolanum ...
C149H246N56O44S
Sermorelin
The Native GHRH Analogue for Diagnostic and Therapeutic Research
Sermorelin is a synthetic peptide consisting of the first 29 amino acids of naturally occurring growth hormone...
C187H291N45O59
Semaglutide
The Long-Acting GLP-1 Receptor Agonist
Semaglutide is a synthetic GLP-1 (glucagon-like peptide-1) receptor agonist developed by Novo Nordisk, structu...
C225H348N60O68
Tirzepatide
The Dual GIP/GLP-1 "Twincretin" Receptor Agonist
Tirzepatide is a synthetic dual agonist of both the GIP (glucose-dependent insulinotropic polypeptide) and GLP...
C221H352N56O67
Retatrutide
The Triple Hormone Receptor Agonist (GLP-1/GIP/Glucagon)
Retatrutide (LY3437943) is an investigational triple receptor agonist targeting GLP-1, GIP, and glucagon recep...
C10H11N2
5-Amino-1MQ
NNMT Inhibitor — Small Molecule for Fat Oxidation
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (N...
C174H294N44O52S2
Cagrilintide
Long-Acting Amylin Analogue for Appetite Regulation
Cagrilintide is a long-acting synthetic analogue of human amylin, a peptide co-secreted with insulin from panc...
Eloralintide
Investigational Long-Acting GLP-1 Receptor Agonist
Eloralintide is an investigational long-acting GLP-1 receptor agonist in the incretin therapy class, engineere...
C990H1528N262O300S7
HGH 191aa (Somatropin)
Recombinant Human Growth Hormone — 191 Amino Acid Sequence
HGH 191aa (Somatropin) is recombinant human growth hormone consisting of the complete 191-amino-acid sequence ...
SLU-PP-332
The Pan-ERR Agonist Exercise Mimetic
SLU-PP-332 is a synthetic pan-ERR (estrogen-related receptor α, β, γ) agonist developed in Thomas Burris's lab...
Knowledge Base
Research Articles
Educational guides and mechanism explanations relevant to weight loss research.
Tesamorelin: Clinical Data for Visceral Fat Reduction
Phase III trial data showing 15-18% visceral fat reduction and the FDA approval rationale for Egrifta®.
AOD-9604: Lipolysis Without Growth Effects
How AOD-9604's C-terminus fragment of HGH stimulates lipolysis without the growth-promoting effects of full-length HGH.
CJC-1295 + Ipamorelin: Synergistic GH Secretagogue Research
Examining the complementary mechanisms of CJC-1295 (GHRH analogue) and Ipamorelin (ghrelin mimetic) in research settings.
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