Epitalon
The Telomere Peptide — Resets the Biological Clock
Epitalon (Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the natural polypeptide Epithalamin, produced by the pineal gland. Developed by Russian gerontologis...
Formula
C14H22N4O9
Molecular Weight
390.34 g/mol
Sequence
Ala-Glu-Asp-Gly
What is this compound?
Epitalon (Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the natural polypeptide Epithalamin, produced by the pineal gland. Developed by Russian gerontologist Vladimir Khavinson, it has been studied for over 35 years. Research demonstrates its ability to elongate telomeres, regulate the neuroendocrine system, and extend lifespan in both invertebrate and mammalian models.
Telomerase activation and telomere elongation
Pineal gland melatonin regulation
Normalization of neuroendocrine function with age
Lifespan extension in multiple research model organisms
Antioxidant and DNA repair enhancement
Cancer incidence reduction in aged animal models
How it works
Epitalon activates telomerase (hTERT), the enzyme responsible for adding telomeric repeats to chromosome ends, counteracting the shortening that occurs with each cell division. It also regulates the expression of genes involved in cell cycle control, apoptosis, and oxidative stre...
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Discovery to present
1980s
Discovery
Epitalon was first identified and characterized in research contexts.
2000s
Research
Preclinical studies expanded across multiple tissue types and disease models.
2010s
Clinical Progress
Early-stage research progressed toward translational and clinical investigation.
2024+
Current Interest
Active research continues with growing scientific interest and expanding publication volume.
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Primary literature
Reference compilation in progress. See research highlights below.
Khavinson's 40-year research shows 30-50% increase in lifespan in rats and fruit flies
Khavinson's 40-year research shows 30-50% increase in lifespan in rats and fruit flies
Human trials in elderly patients show normalization of melatonin levels and immune function
Human trials in elderly patients show normalization of melatonin levels and immune function
Telomere length studies confirm telomerase activation and telomere lengthening in somatic cells
Telomere length studies confirm telomerase activation and telomere lengthening in somatic cells
Epitalon — Frequently asked
Epitalon (Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the natural polypeptide Epithalamin, produced by the pineal gland. Developed by Russian gerontologist Vladimir Khavinson... Epitalon belongs to the Anti Aging research category and is studied for its the telomere peptide — resets the biological clock.
Epitalon activates telomerase (hTERT), the enzyme responsible for adding telomeric repeats to chromosome ends, counteracting the shortening that occurs with each cell division. It also regulates the expression of genes involved in cell cycle control, apoptosis, and oxidative stress response. Interaction with the pineal gland normalizes melatonin and cortisol rhythms.
Telomerase activation and telomere elongation. Pineal gland melatonin regulation. Normalization of neuroendocrine function with age. Lifespan extension in multiple research model organisms. Antioxidant and DNA repair enhancement. Cancer incidence reduction in aged animal models.
Epitalon has the molecular formula C14H22N4O9 and a molecular weight of 390.34 g/mol. Its amino acid sequence is Ala-Glu-Asp-Gly. This structural information is important for researchers studying receptor binding and pharmacokinetics.
Khavinson's 40-year research shows 30-50% increase in lifespan in rats and fruit flies Human trials in elderly patients show normalization of melatonin levels and immune function Telomere length studies confirm telomerase activation and telomere lengthening in somatic cells These findings are based on preclinical and clinical research. Epitalon is a research compound and these studies do not constitute medical advice.
No. Epitalon is not FDA-approved for any indication. It is a research chemical studied in preclinical and early clinical research. These compounds are not approved for human therapeutic use and should only be studied in appropriate research settings.
Epitalon belongs to the Anti Aging category, which focuses on peptides researched for their telomere-supporting, mitochondrial-protective, and senolytic properties aligned with healthy longevity science. You can explore more compounds in this category on the Anti Aging pillar page.
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Research Disclaimer
Epitalon is a research compound. All information is for educational and research purposes only. Not intended for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease.