Epitalon
The Telomere Peptide — Resets the Biological Clock
Molecular Data
- Formula
- C14H22N4O9
- Molecular Weight
- 390.34 g/mol
- Sequence
- Ala-Glu-Asp-Gly
01
Overview
Epitalon (Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the natural polypeptide Epithalamin, produced by the pineal gland. Developed by Russian gerontologist Vladimir Khavinson, it has been studied for over 35 years. Research demonstrates its ability to elongate telomeres, regulate the neuroendocrine system, and extend lifespan in both invertebrate and mammalian models.
02
Mechanism of Action
Epitalon activates telomerase (hTERT), the enzyme responsible for adding telomeric repeats to chromosome ends, counteracting the shortening that occurs with each cell division. It also regulates the expression of genes involved in cell cycle control, apoptosis, and oxidative stress response. Interaction with the pineal gland normalizes melatonin and cortisol rhythms.
03
Research Highlights
Khavinson's 40-year research shows 30-50% increase in lifespan in rats and fruit flies
Human trials in elderly patients show normalization of melatonin levels and immune function
Telomere length studies confirm telomerase activation and telomere lengthening in somatic cells
04
Dosage
Administration & Timing
Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue or intranasal, typically 1–2× daily. Research protocols commonly use 10–20 day courses; timing independent of food.
Dosage Guidelines
Cycle Length
10–20 day courses, repeated 1–3× per year in longevity research.
05
Reconstitution
Solvent
Bacteriostatic Water (0.9% benzyl alcohol)
Volume
1 mL added to a 50 mg vial
Concentration
50 mg/mL
Storage
Lyophilized powder: store at -20 °C long-term. Reconstituted: refrigerate 2–8 °C, use within 30 days.
Notes
Epitalon (Epithalon) is a tetrapeptide (Ala-Glu-Asp-Gly). Short pulsing courses are favored over continuous dosing in longevity research.
Research Reference Only
Dosage and reconstitution values reflect commonly cited ranges from published research literature and are presented for educational and research reference only. This is not medical advice or a dosing recommendation. HEXAGEN does not endorse human use of any compound. Always consult a qualified healthcare professional.
Research Disclaimer
Epitalon is for educational and research purposes only. Not intended as medical advice. Consult a qualified healthcare professional before making any health-related decisions.
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Epitalon — Common Research Questions
What is Epitalon?
Epitalon (Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the natural polypeptide Epithalamin, produced by the pineal gland. Developed by Russian gerontologist Vladimir Khavinson... Epitalon belongs to the Anti Aging research category and is studied for its the telomere peptide — resets the biological clock.
How does Epitalon work?
Epitalon activates telomerase (hTERT), the enzyme responsible for adding telomeric repeats to chromosome ends, counteracting the shortening that occurs with each cell division. It also regulates the expression of genes involved in cell cycle control, apoptosis, and oxidative stress response. Interaction with the pineal gland normalizes melatonin and cortisol rhythms.
What are the key research benefits of Epitalon?
Telomerase activation and telomere elongation. Pineal gland melatonin regulation. Normalization of neuroendocrine function with age. Lifespan extension in multiple research model organisms. Antioxidant and DNA repair enhancement. Cancer incidence reduction in aged animal models.
What is the molecular structure of Epitalon?
Epitalon has the molecular formula C14H22N4O9 and a molecular weight of 390.34 g/mol. Its amino acid sequence is Ala-Glu-Asp-Gly. This structural information is important for researchers studying receptor binding and pharmacokinetics.
What does the research say about Epitalon?
Khavinson's 40-year research shows 30-50% increase in lifespan in rats and fruit flies Human trials in elderly patients show normalization of melatonin levels and immune function Telomere length studies confirm telomerase activation and telomere lengthening in somatic cells These findings are based on preclinical and clinical research. Epitalon is a research compound and these studies do not constitute medical advice.
Is Epitalon FDA approved?
No. Epitalon is not FDA-approved for any indication. It is a research chemical studied in preclinical and early clinical research. These compounds are not approved for human therapeutic use and should only be studied in appropriate research settings.
What category does Epitalon belong to?
Epitalon belongs to the Anti Aging category, which focuses on peptides researched for their telomere-supporting, mitochondrial-protective, and senolytic properties aligned with healthy longevity science. You can explore more compounds in this category on the Anti Aging pillar page.
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Epitalon: Telomerase Activation and Lifespan Research
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Scientific References
Khavinson et al. — "Epitalon: telomere elongation and lifespan" (Bull Exp Biol Med, 2003)
Khavinson & Morozov — 35-year gerontology research, 2020
Human trials: melatonin and immune normalization in elderly
Khavinson's 40-year research shows 30-50% increase in lifespan in rats and fruit flies
Human trials in elderly patients show normalization of melatonin levels and immune function
Telomere length studies confirm telomerase activation and telomere lengthening in somatic cells