Dihexa
The Synaptogenic Peptide — Next-Level Cognitive Enhancement
01
Overview
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a potent cognitive enhancer developed at Washington State University. It is derived from angiotensin IV and has been shown in preclinical research to be approximately 10 million times more potent than BDNF at inducing new synapse formation — a process critical for learning and memory.
02
Mechanism of Action
Dihexa binds to hepatocyte growth factor (HGF) and facilitates its interaction with the MET receptor (c-Met), triggering downstream signaling cascades that promote dendritic spine formation and synaptogenesis. It bypasses the blood-brain barrier and operates at extremely low concentrations.
03
Research Highlights
Washington State University research showing 10M× greater potency than BDNF in synaptogenesis
Morris water maze studies show dramatic spatial memory improvement in aged animals
Research on Parkinson's and Alzheimer's models shows neuroprotective synaptogenic activity
04
Dosage
Administration & Timing
Oral administration (capsule or solution) or Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue. Research protocols typically use once-daily oral administration; timing independent of food.
Dosage Guidelines
Cycle Length
2–4 weeks; longer protocols (8–12 weeks) documented in cognitive decline research.
05
Reconstitution
Solvent
Bacteriostatic Water (0.9% benzyl alcohol)
Volume
2 mL added to a 20 mg vial (for SC research)
Concentration
10 mg/mL
Storage
Lyophilized powder: store at -20 °C long-term. Reconstituted: refrigerate 2–8 °C, use within 30 days.
Notes
Dihexa is orders of magnitude more potent than BDNF in synaptogenesis assays. Use microgram-level precision in research dosing.
Research Reference Only
Dosage and reconstitution values reflect commonly cited ranges from published research literature and are presented for educational and research reference only. This is not medical advice or a dosing recommendation. HEXAGEN does not endorse human use of any compound. Always consult a qualified healthcare professional.
Research Disclaimer
Dihexa is for educational and research purposes only. Not intended as medical advice. Consult a qualified healthcare professional before making any health-related decisions.
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Dihexa — Common Research Questions
What is Dihexa?
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a potent cognitive enhancer developed at Washington State University. It is derived from angiotensin IV and has been shown in preclinical researc... Dihexa belongs to the Cognitive research category and is studied for its the synaptogenic peptide — next-level cognitive enhancement.
How does Dihexa work?
Dihexa binds to hepatocyte growth factor (HGF) and facilitates its interaction with the MET receptor (c-Met), triggering downstream signaling cascades that promote dendritic spine formation and synaptogenesis. It bypasses the blood-brain barrier and operates at extremely low concentrations.
What are the key research benefits of Dihexa?
Synaptogenesis — formation of new neural connections. Dramatic improvement in spatial memory in research models. Alzheimer's and neurodegeneration model research. Long-lasting cognitive enhancement. Hippocampal neuroplasticity promotion. Potential rescue of cognitive deficits in degenerative models.
What is the molecular structure of Dihexa?
Dihexa is a research compound in the Cognitive category. Detailed molecular structure data is being compiled. Refer to primary literature for structural analysis.
What does the research say about Dihexa?
Washington State University research showing 10M× greater potency than BDNF in synaptogenesis Morris water maze studies show dramatic spatial memory improvement in aged animals Research on Parkinson's and Alzheimer's models shows neuroprotective synaptogenic activity These findings are based on preclinical and clinical research. Dihexa is a research compound and these studies do not constitute medical advice.
Is Dihexa FDA approved?
No. Dihexa is not FDA-approved for any indication. It is a research chemical studied in preclinical and early clinical research. These compounds are not approved for human therapeutic use and should only be studied in appropriate research settings.
What category does Dihexa belong to?
Dihexa belongs to the Cognitive category, which focuses on peptides investigated for their nootropic and neuroprotective potential, supporting mental clarity, memory consolidation, and neurological resilience. You can explore more compounds in this category on the Cognitive pillar page.
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Scientific References
Wright et al. — Washington State Univ synaptogenesis research (J Pharmacol Exp Ther, 2012)
Wright et al. — Morris water maze spatial memory study, 2017
Washington State University research showing 10M× greater potency than BDNF in synaptogenesis
Morris water maze studies show dramatic spatial memory improvement in aged animals
Research on Parkinson's and Alzheimer's models shows neuroprotective synaptogenic activity