KPV
The Anti-Inflammatory Tripeptide
Molecular Data
- Formula
- C16H30N4O5
- Molecular Weight
- 358.43 g/mol
- Sequence
- Lys-Pro-Val
01
Overview
KPV is a naturally derived tripeptide (Lys-Pro-Val) representing the C-terminal sequence of the endogenous peptide α-MSH (alpha-melanocyte-stimulating hormone). Despite its small size, KPV demonstrates potent anti-inflammatory properties and has been studied extensively in gut and skin inflammation research models.
02
Mechanism of Action
KPV inhibits NF-κB activation, a master regulator of the inflammatory response. It interacts with melanocortin receptors (MC1R, MC3R) to suppress cytokine production and can penetrate colonocyte membranes directly. It modulates macrophage polarization toward an anti-inflammatory M2 phenotype.
03
Research Highlights
Colitis models show significant reduction in inflammatory markers and mucosal damage
Dermal studies indicate reduction in inflammatory cytokine expression
Research demonstrates direct intracellular access in epithelial cells
04
Dosage
Administration & Timing
Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue, oral, or intranasal. Research protocols favor once-daily SC administration; oral routes documented in GI-focused research.
Dosage Guidelines
Cycle Length
2–4 weeks; IBD research protocols extend to 6–8 weeks.
05
Reconstitution
Solvent
Bacteriostatic Water (0.9% benzyl alcohol)
Volume
2 mL added to a 5 mg vial
Concentration
2.5 mg/mL (2,500 mcg/mL)
Storage
Refrigerate at 2–8 °C; protect from light. Discard 30 days after reconstitution.
Notes
KPV is a small tripeptide and is stable both orally and parenterally. Reconstituted solution remains potent for 30 days refrigerated.
Research Reference Only
Dosage and reconstitution values reflect commonly cited ranges from published research literature and are presented for educational and research reference only. This is not medical advice or a dosing recommendation. HEXAGEN does not endorse human use of any compound. Always consult a qualified healthcare professional.
Research Disclaimer
KPV is for educational and research purposes only. Not intended as medical advice. Consult a qualified healthcare professional before making any health-related decisions.
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KPV — Common Research Questions
What is KPV?
KPV is a naturally derived tripeptide (Lys-Pro-Val) representing the C-terminal sequence of the endogenous peptide α-MSH (alpha-melanocyte-stimulating hormone). Despite its small size, KPV demonstrate... KPV belongs to the Healing research category and is studied for its the anti-inflammatory tripeptide.
How does KPV work?
KPV inhibits NF-κB activation, a master regulator of the inflammatory response. It interacts with melanocortin receptors (MC1R, MC3R) to suppress cytokine production and can penetrate colonocyte membranes directly. It modulates macrophage polarization toward an anti-inflammatory M2 phenotype.
What are the key research benefits of KPV?
Powerful anti-inflammatory signaling. Intestinal barrier protection and repair. Reduction of pro-inflammatory cytokines (TNF-α, IL-6). Skin inflammation modulation. Minimal systemic side-effect profile in research. Potential benefit in inflammatory bowel disease models.
What is the molecular structure of KPV?
KPV has the molecular formula C16H30N4O5 and a molecular weight of 358.43 g/mol. Its amino acid sequence is Lys-Pro-Val. This structural information is important for researchers studying receptor binding and pharmacokinetics.
What does the research say about KPV?
Colitis models show significant reduction in inflammatory markers and mucosal damage Dermal studies indicate reduction in inflammatory cytokine expression Research demonstrates direct intracellular access in epithelial cells These findings are based on preclinical and clinical research. KPV is a research compound and these studies do not constitute medical advice.
Is KPV FDA approved?
No. KPV is not FDA-approved for any indication. It is a research chemical studied in preclinical and early clinical research. These compounds are not approved for human therapeutic use and should only be studied in appropriate research settings.
What category does KPV belong to?
KPV belongs to the Healing category, which focuses on research-grade peptides studied for their regenerative and healing properties, supporting tissue repair, inflammation modulation, and systemic recovery. You can explore more compounds in this category on the Healing pillar page.
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Scientific References
Marroni et al. — KPV in inflammatory bowel disease models, Int J Mol Sci, 2021
Brzoska et al. — α-MSH-derived peptides and NF-κB, Endocrine Rev, 2008
Colitis models show significant reduction in inflammatory markers and mucosal damage
Dermal studies indicate reduction in inflammatory cytokine expression
Research demonstrates direct intracellular access in epithelial cells