VIP
Vasoactive Intestinal Peptide — The Regulatory Neuropeptide
Molecular Data
- Formula
- C147H237N43O43S
- Molecular Weight
- 3326.8 g/mol
01
Overview
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide widely distributed in the central and peripheral nervous system, the gut, and the lungs. It plays a broad regulatory role in immune function, smooth muscle relaxation, circadian rhythm, and neurotransmission. Research highlights its powerful anti-inflammatory and cytoprotective properties.
02
Mechanism of Action
VIP binds to VPAC1 and VPAC2 receptors, activating adenylate cyclase and elevating cAMP, leading to downstream anti-inflammatory signaling. It suppresses Th1 cytokines (TNF-α, IL-6, IL-12) and promotes Th2 responses and regulatory T-cells.
03
Research Highlights
Rheumatoid arthritis models show significant reduction in joint inflammation
Pulmonary hypertension research demonstrates vasodilatory and anti-remodeling effects
MCAS and mast cell research highlights immunomodulatory therapeutic potential
04
Dosage
Administration & Timing
Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue or intranasal. Research protocols typically administer once or twice daily; intranasal route used in neuroinflammation research.
Dosage Guidelines
Cycle Length
2–4 weeks; chronic pulmonary research extends to 8–12 weeks.
05
Reconstitution
Solvent
Bacteriostatic Water (0.9% benzyl alcohol)
Volume
2 mL added to a 1 mg vial
Concentration
0.5 mg/mL (500 mcg/mL)
Storage
Refrigerate at 2–8 °C; protect from light. Discard 30 days after reconstitution.
Notes
VIP is potent and fast-acting; start at the low end of research ranges. Monitor blood pressure — vasodilation may cause transient hypotension.
Research Reference Only
Dosage and reconstitution values reflect commonly cited ranges from published research literature and are presented for educational and research reference only. This is not medical advice or a dosing recommendation. HEXAGEN does not endorse human use of any compound. Always consult a qualified healthcare professional.
Research Disclaimer
VIP is for educational and research purposes only. Not intended as medical advice. Consult a qualified healthcare professional before making any health-related decisions.
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VIP Knowledge Graph
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VIP — Common Research Questions
What is VIP?
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide widely distributed in the central and peripheral nervous system, the gut, and the lungs. It plays a broad regulatory role in immune ... VIP belongs to the Healing research category and is studied for its vasoactive intestinal peptide — the regulatory neuropeptide.
How does VIP work?
VIP binds to VPAC1 and VPAC2 receptors, activating adenylate cyclase and elevating cAMP, leading to downstream anti-inflammatory signaling. It suppresses Th1 cytokines (TNF-α, IL-6, IL-12) and promotes Th2 responses and regulatory T-cells.
What are the key research benefits of VIP?
Smooth muscle relaxation and vasodilation. Potent anti-inflammatory cytokine modulation. Neuroprotective effects in neuroinflammation models. Circadian rhythm and sleep regulation. Pulmonary and GI tract relaxation. Autoimmune condition modulation in research.
What is the molecular structure of VIP?
VIP has the molecular formula C147H237N43O43S and a molecular weight of 3326.8 g/mol. This structural information is important for researchers studying receptor binding and pharmacokinetics.
What does the research say about VIP?
Rheumatoid arthritis models show significant reduction in joint inflammation Pulmonary hypertension research demonstrates vasodilatory and anti-remodeling effects MCAS and mast cell research highlights immunomodulatory therapeutic potential These findings are based on preclinical and clinical research. VIP is a research compound and these studies do not constitute medical advice.
Is VIP FDA approved?
No. VIP is not FDA-approved for any indication. It is a research chemical studied in preclinical and early clinical research. These compounds are not approved for human therapeutic use and should only be studied in appropriate research settings.
What category does VIP belong to?
VIP belongs to the Healing category, which focuses on research-grade peptides studied for their regenerative and healing properties, supporting tissue repair, inflammation modulation, and systemic recovery. You can explore more compounds in this category on the Healing pillar page.
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Scientific References
Delgado et al. — "Vasoactive Intestinal Peptide in immune response" (Immunol Rev, 2021)
Henning et al. — Pulmonary hypertension vasodilation, Pulm Pharmacol Ther, 2008
Rheumatoid arthritis models show significant reduction in joint inflammation
Pulmonary hypertension research demonstrates vasodilatory and anti-remodeling effects
MCAS and mast cell research highlights immunomodulatory therapeutic potential