DSIP
Delta Sleep-Inducing Peptide — Rest and Recovery
Molecular Data
- Formula
- C35H48N10O15
- Molecular Weight
- 848.81 g/mol
- Sequence
- Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
01
Overview
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuromodulatory nonapeptide identified in 1974 that promotes deep delta-wave sleep. Beyond sleep regulation, research has uncovered its broad physiological roles including stress modulation, hormonal balance, and antioxidant activity.
02
Mechanism of Action
DSIP modulates hypothalamic-pituitary-adrenal (HPA) axis activity, reducing stress-induced cortisol and ACTH release. It interacts with opiate and serotonin receptors and appears to reduce oxidative stress through antioxidant enzyme upregulation.
03
Research Highlights
Initial discovery research demonstrated profound sleep-inducing effects in rabbits
Stress reduction studies show normalization of elevated cortisol and stress markers
Antioxidant research indicates protective effects on mitochondrial function
04
Dosage
Administration & Timing
Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue or intranasal, administered 30–60 minutes before sleep in circadian research protocols.
Dosage Guidelines
Cycle Length
1–3 weeks; intermittent use documented in long-term stress research.
05
Reconstitution
Solvent
Bacteriostatic Water (0.9% benzyl alcohol)
Volume
2 mL added to a 5 mg vial
Concentration
2.5 mg/mL (2,500 mcg/mL)
Storage
Refrigerate at 2–8 °C; protect from light. Discard 30 days after reconstitution.
Notes
DSIP is administered in the evening to align with endogenous delta-wave sleep onset. Avoid daytime dosing in sleep-focused protocols.
Research Reference Only
Dosage and reconstitution values reflect commonly cited ranges from published research literature and are presented for educational and research reference only. This is not medical advice or a dosing recommendation. HEXAGEN does not endorse human use of any compound. Always consult a qualified healthcare professional.
Research Disclaimer
DSIP is for educational and research purposes only. Not intended as medical advice. Consult a qualified healthcare professional before making any health-related decisions.
Related Compounds
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DSIP — Common Research Questions
What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuromodulatory nonapeptide identified in 1974 that promotes deep delta-wave sleep. Beyond sleep regulation, research has uncovered its bro... DSIP belongs to the Healing research category and is studied for its delta sleep-inducing peptide — rest and recovery.
How does DSIP work?
DSIP modulates hypothalamic-pituitary-adrenal (HPA) axis activity, reducing stress-induced cortisol and ACTH release. It interacts with opiate and serotonin receptors and appears to reduce oxidative stress through antioxidant enzyme upregulation.
What are the key research benefits of DSIP?
Deep delta-wave sleep promotion. Stress hormone (ACTH, cortisol) normalization. Antioxidant and cytoprotective properties. Circadian rhythm entrainment. LH and GH pulsatile release modulation. Potential neuroprotective effects.
What is the molecular structure of DSIP?
DSIP has the molecular formula C35H48N10O15 and a molecular weight of 848.81 g/mol. Its amino acid sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. This structural information is important for researchers studying receptor binding and pharmacokinetics.
What does the research say about DSIP?
Initial discovery research demonstrated profound sleep-inducing effects in rabbits Stress reduction studies show normalization of elevated cortisol and stress markers Antioxidant research indicates protective effects on mitochondrial function These findings are based on preclinical and clinical research. DSIP is a research compound and these studies do not constitute medical advice.
Is DSIP FDA approved?
No. DSIP is not FDA-approved for any indication. It is a research chemical studied in preclinical and early clinical research. These compounds are not approved for human therapeutic use and should only be studied in appropriate research settings.
What category does DSIP belong to?
DSIP belongs to the Healing category, which focuses on research-grade peptides studied for their regenerative and healing properties, supporting tissue repair, inflammation modulation, and systemic recovery. You can explore more compounds in this category on the Healing pillar page.
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Scientific References
Schoenenberger & Monnier — "DSIP: Sleep-inducing peptide" (Pflugers Arch, 1977)
Gafurov et al. — Stress modulation and HPA axis, Pathophysiology, 2017
Initial discovery research demonstrated profound sleep-inducing effects in rabbits
Stress reduction studies show normalization of elevated cortisol and stress markers
Antioxidant research indicates protective effects on mitochondrial function