HGH 191aa (Somatropin)
Recombinant Human Growth Hormone — 191 Amino Acid Sequence
Molecular Data
- Formula
- C990H1528N262O300S7
- Molecular Weight
- 22124.0 g/mol
- Sequence
- FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFS…
01
Overview
HGH 191aa (Somatropin) is recombinant human growth hormone consisting of the complete 191-amino-acid sequence identical to endogenous pituitary GH. Produced via recombinant DNA technology in E. coli or mammalian cell expression systems, it is FDA-approved for growth hormone deficiency, Turner syndrome, and several pediatric growth disorders. In metabolic research, GH is studied for its lipolytic, anabolic, and body composition effects.
02
Mechanism of Action
Somatropin binds the growth hormone receptor (GHR) on target tissues, activating the JAK2/STAT5b signaling pathway. In the liver, this stimulates IGF-1 synthesis, which mediates anabolic growth effects. Direct GH action on adipocytes activates hormone-sensitive lipase via cAMP, promoting lipolysis and fatty acid mobilization. GH also antagonizes insulin action, increasing gluconeogenesis and free fatty acid availability.
03
Research Highlights
GH-deficient adult replacement studies show significant reduction in visceral adipose tissue
Body composition research demonstrates increased lean mass and decreased fat mass with physiological dosing
Recombinant 191aa bioequivalence studies confirm identical pharmacokinetics to pituitary-derived GH
04
Dosage
Administration & Timing
Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue or Intramuscular (IM) injection, once daily. Pharmaceutical somatropin (Genotropin®, Humatrope®, Norditropin®); research administers at bedtime to mimic endogenous GH pulsatility.
Dosage Guidelines
Cycle Length
Indefinite in approved deficiencies; research cycles 12–24 weeks with IGF-1 monitoring.
05
Reconstitution
Solvent
Supplied with manufacturer diluent (bacteriostatic or sterile water)
Volume
Per product cartridge (e.g., 1 mL to 5–10 mg)
Concentration
5–10 mg/mL (15–30 IU/mL)
Storage
Refrigerate 2–8 °C; use within 14–28 days depending on formulation. Do not freeze.
Notes
Recombinant 191-amino-acid hGH. Rotate SC sites (abdomen, thigh). Monitor IGF-1 and fasting glucose.
Research Reference Only
Dosage and reconstitution values reflect commonly cited ranges from published research literature and are presented for educational and research reference only. This is not medical advice or a dosing recommendation. HEXAGEN does not endorse human use of any compound. Always consult a qualified healthcare professional.
Research Disclaimer
HGH 191aa (Somatropin) is for educational and research purposes only. Not intended as medical advice. Consult a qualified healthcare professional before making any health-related decisions.
Related Compounds
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HGH 191aa (Somatropin) — Common Research Questions
What is HGH 191aa (Somatropin)?
HGH 191aa (Somatropin) is recombinant human growth hormone consisting of the complete 191-amino-acid sequence identical to endogenous pituitary GH. Produced via recombinant DNA technology in E. coli o... HGH 191aa (Somatropin) belongs to the Weight Loss research category and is studied for its recombinant human growth hormone — 191 amino acid sequence.
How does HGH 191aa (Somatropin) work?
Somatropin binds the growth hormone receptor (GHR) on target tissues, activating the JAK2/STAT5b signaling pathway. In the liver, this stimulates IGF-1 synthesis, which mediates anabolic growth effects. Direct GH action on adipocytes activates hormone-sensitive lipase via cAMP, promoting lipolysis and fatty acid mobilization. GH also antagonizes insulin action, increasing gluconeogenesis and free fatty acid availability.
What are the key research benefits of HGH 191aa (Somatropin)?
Identical 191-amino-acid sequence to native human GH. Potent lipolytic effect on visceral and subcutaneous adipose tissue. Lean body mass preservation and augmentation. IGF-1 mediation of anabolic tissue growth. Metabolic rate enhancement via direct GH receptor action. Established clinical safety database across pediatric and adult indications.
What is the molecular structure of HGH 191aa (Somatropin)?
HGH 191aa (Somatropin) has the molecular formula C990H1528N262O300S7 and a molecular weight of 22124.0 g/mol. Its amino acid sequence is FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNRRETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLIVYGQDSLSTDTNAMETLRQVKWELALAEFRSLYDRNLANSFVASQKLSLKIIDPLVDTQYSKFVQNSIDNQDSIYLLDKMQAEFDKAFEHSLLSHADTVCVEVDEQHPSLEGSVMESTFHEMREAEQEQ. This structural information is important for researchers studying receptor binding and pharmacokinetics.
What does the research say about HGH 191aa (Somatropin)?
GH-deficient adult replacement studies show significant reduction in visceral adipose tissue Body composition research demonstrates increased lean mass and decreased fat mass with physiological dosing Recombinant 191aa bioequivalence studies confirm identical pharmacokinetics to pituitary-derived GH These findings are based on preclinical and clinical research. HGH 191aa (Somatropin) is a research compound and these studies do not constitute medical advice.
Is HGH 191aa (Somatropin) FDA approved?
Yes. Somatropin (recombinant HGH 191aa) is FDA-approved for growth hormone deficiency, Turner syndrome, and several pediatric growth disorders.
What category does HGH 191aa (Somatropin) belong to?
HGH 191aa (Somatropin) belongs to the Weight Loss category, which focuses on compounds studied for their roles in metabolic regulation, growth hormone signaling, and targeted adipose tissue reduction. You can explore more compounds in this category on the Weight Loss pillar page.
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Scientific References
GH-deficient adult replacement studies show significant reduction in visceral adipose tissue
Body composition research demonstrates increased lean mass and decreased fat mass with physiological dosing
Recombinant 191aa bioequivalence studies confirm identical pharmacokinetics to pituitary-derived GH