Hexarelin
The Potent GH Secretagogue with Cardioprotective Action
Molecular Data
- Formula
- C47H58N12O6
- Molecular Weight
- 887.04 g/mol
- Sequence
- His-D-2MeTrp-Ala-Trp-D-Phe-Lys-NH2
01
Overview
Hexarelin (Examorelin) is a synthetic hexapeptide and potent ghrelin receptor agonist developed by Mediolanum Farmaceutici. It is among the most powerful GH secretagogues studied, producing GH pulses greater than GHRP-6. Beyond GH release, it exhibits direct cardioprotective effects independent of GH, making it a compound of significant cardiology research interest.
02
Mechanism of Action
Hexarelin binds GHS-R1a with high affinity, stimulating robust GH release. Its cardioprotective effects appear to involve a distinct cardiac binding site independent of the ghrelin receptor, activating survival kinases including PI3K/Akt and ERK1/2 in cardiomyocytes, reducing calcium overload and oxidative damage during ischemia.
03
Research Highlights
Comparative secretagogue studies show GH pulses exceeding GHRP-6 and GHRP-2 at equivalent doses
Isolated heart perfusion models demonstrate improved post-ischemic recovery and reduced infarct size
Cardiomyopathy research in rodents shows preserved ejection fraction and reduced fibrotic remodeling
04
Dosage
Administration & Timing
Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue, 1–2× daily. Research protocols administer on an empty stomach; bedtime dosing common.
Dosage Guidelines
Cycle Length
4–8 weeks; followed by 2–4 week rest.
05
Reconstitution
Solvent
Bacteriostatic Water (0.9% benzyl alcohol)
Volume
2 mL added to a 5 mg vial
Concentration
2.5 mg/mL (2,500 mcg/mL)
Storage
Refrigerate at 2–8 °C; protect from light. Discard 30 days after reconstitution.
Notes
Hexarelin produces a stronger GH pulse than GHRP-6 but desensitization occurs faster — cap at 2 doses/day in research.
Research Reference Only
Dosage and reconstitution values reflect commonly cited ranges from published research literature and are presented for educational and research reference only. This is not medical advice or a dosing recommendation. HEXAGEN does not endorse human use of any compound. Always consult a qualified healthcare professional.
Research Disclaimer
Hexarelin is for educational and research purposes only. Not intended as medical advice. Consult a qualified healthcare professional before making any health-related decisions.
Related Compounds
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Hexarelin — Common Research Questions
What is Hexarelin?
Hexarelin (Examorelin) is a synthetic hexapeptide and potent ghrelin receptor agonist developed by Mediolanum Farmaceutici. It is among the most powerful GH secretagogues studied, producing GH pulses ... Hexarelin belongs to the Weight Loss research category and is studied for its the potent gh secretagogue with cardioprotective action.
How does Hexarelin work?
Hexarelin binds GHS-R1a with high affinity, stimulating robust GH release. Its cardioprotective effects appear to involve a distinct cardiac binding site independent of the ghrelin receptor, activating survival kinases including PI3K/Akt and ERK1/2 in cardiomyocytes, reducing calcium overload and oxidative damage during ischemia.
What are the key research benefits of Hexarelin?
Among the most potent GH secretagogue pulses documented. Direct cardioprotective effects independent of GH axis. Enhanced coronary blood flow in research models. Preservation of cardiac function after ischemic injury. Potential fibrosis reduction in cardiac tissue. Sustained GH response without rapid desensitization.
What is the molecular structure of Hexarelin?
Hexarelin has the molecular formula C47H58N12O6 and a molecular weight of 887.04 g/mol. Its amino acid sequence is His-D-2MeTrp-Ala-Trp-D-Phe-Lys-NH2. This structural information is important for researchers studying receptor binding and pharmacokinetics.
What does the research say about Hexarelin?
Comparative secretagogue studies show GH pulses exceeding GHRP-6 and GHRP-2 at equivalent doses Isolated heart perfusion models demonstrate improved post-ischemic recovery and reduced infarct size Cardiomyopathy research in rodents shows preserved ejection fraction and reduced fibrotic remodeling These findings are based on preclinical and clinical research. Hexarelin is a research compound and these studies do not constitute medical advice.
Is Hexarelin FDA approved?
No. Hexarelin is not FDA-approved for any indication. It is a research chemical studied in preclinical and early clinical research. These compounds are not approved for human therapeutic use and should only be studied in appropriate research settings.
What category does Hexarelin belong to?
Hexarelin belongs to the Weight Loss category, which focuses on compounds studied for their roles in metabolic regulation, growth hormone signaling, and targeted adipose tissue reduction. You can explore more compounds in this category on the Weight Loss pillar page.
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Scientific References
Comparative secretagogue studies show GH pulses exceeding GHRP-6 and GHRP-2 at equivalent doses
Isolated heart perfusion models demonstrate improved post-ischemic recovery and reduced infarct size
Cardiomyopathy research in rodents shows preserved ejection fraction and reduced fibrotic remodeling