GHRP-6
Growth Hormone Releasing Peptide-6
Molecular Data
- Formula
- C46H56N12O6
- Molecular Weight
- 873.01 g/mol
- Sequence
- His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
01
Overview
GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide and one of the earliest discovered ghrelin receptor agonists. It potently stimulates GH release while also significantly increasing appetite through ghrelin mimicry. Research examines its dual role in metabolic regulation and recovery, with data spanning body composition, cardioprotection, and post-injury tissue repair.
02
Mechanism of Action
GHRP-6 binds the ghrelin receptor (GHS-R1a) on pituitary somatotrophs and simultaneously suppresses somatostatin tone, producing a strong GH secretory pulse. Its orexigenic effect arises from hypothalamic NPY and AgRP neuron activation, distinguishing it from GHRP-2 by a more pronounced appetite signal.
03
Research Highlights
Dose-response studies confirm reliable GH elevation within 15-30 minutes of administration
Cardiac ischemia models demonstrate reduced cardiomyocyte apoptosis and improved functional recovery
Combination studies with GHRH analogues show multiplicative GH pulse amplification
04
Dosage
Administration & Timing
Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue, 1–3× daily. Research protocols administer on an empty stomach (avoid food 30 min before/after).
Dosage Guidelines
Cycle Length
4–8 weeks; followed by 2–4 week rest.
05
Reconstitution
Solvent
Bacteriostatic Water (0.9% benzyl alcohol)
Volume
2 mL added to a 5 mg vial
Concentration
2.5 mg/mL (2,500 mcg/mL)
Storage
Refrigerate at 2–8 °C; protect from light. Discard 30 days after reconstitution.
Notes
GHRP-6 produces the strongest ghrelin-like appetite stimulation of the GHRPs. Fasting 30 min pre/post preserves GH pulse amplitude.
Research Reference Only
Dosage and reconstitution values reflect commonly cited ranges from published research literature and are presented for educational and research reference only. This is not medical advice or a dosing recommendation. HEXAGEN does not endorse human use of any compound. Always consult a qualified healthcare professional.
Research Disclaimer
GHRP-6 is for educational and research purposes only. Not intended as medical advice. Consult a qualified healthcare professional before making any health-related decisions.
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GHRP-6 — Common Research Questions
What is GHRP-6?
GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide and one of the earliest discovered ghrelin receptor agonists. It potently stimulates GH release while also significantly increasi... GHRP-6 belongs to the Weight Loss research category and is studied for its growth hormone releasing peptide-6.
How does GHRP-6 work?
GHRP-6 binds the ghrelin receptor (GHS-R1a) on pituitary somatotrophs and simultaneously suppresses somatostatin tone, producing a strong GH secretory pulse. Its orexigenic effect arises from hypothalamic NPY and AgRP neuron activation, distinguishing it from GHRP-2 by a more pronounced appetite signal.
What are the key research benefits of GHRP-6?
Potent GH pulse stimulation. Significant appetite stimulation via ghrelin pathway. Lean body mass preservation in catabolic states. Enhanced recovery and tissue repair signaling. Cardioprotective properties in ischemia research. Synergistic amplification when combined with GHRH analogues.
What is the molecular structure of GHRP-6?
GHRP-6 has the molecular formula C46H56N12O6 and a molecular weight of 873.01 g/mol. Its amino acid sequence is His-D-Trp-Ala-Trp-D-Phe-Lys-NH2. This structural information is important for researchers studying receptor binding and pharmacokinetics.
What does the research say about GHRP-6?
Dose-response studies confirm reliable GH elevation within 15-30 minutes of administration Cardiac ischemia models demonstrate reduced cardiomyocyte apoptosis and improved functional recovery Combination studies with GHRH analogues show multiplicative GH pulse amplification These findings are based on preclinical and clinical research. GHRP-6 is a research compound and these studies do not constitute medical advice.
Is GHRP-6 FDA approved?
No. GHRP-6 is not FDA-approved for any indication. It is a research chemical studied in preclinical and early clinical research. These compounds are not approved for human therapeutic use and should only be studied in appropriate research settings.
What category does GHRP-6 belong to?
GHRP-6 belongs to the Weight Loss category, which focuses on compounds studied for their roles in metabolic regulation, growth hormone signaling, and targeted adipose tissue reduction. You can explore more compounds in this category on the Weight Loss pillar page.
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Scientific References
Dose-response studies confirm reliable GH elevation within 15-30 minutes of administration
Cardiac ischemia models demonstrate reduced cardiomyocyte apoptosis and improved functional recovery
Combination studies with GHRH analogues show multiplicative GH pulse amplification