GHRP-2
Growth Hormone Releasing Peptide-2
Molecular Data
- Formula
- C45H55N9O6
- Molecular Weight
- 817.98 g/mol
- Sequence
- D-Ala-D-βNal-Ala-Trp-D-Phe-Lys-NH2
01
Overview
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide and potent ghrelin receptor agonist. It is one of the most studied GHRPs, capable of stimulating significant GH pulses. Research demonstrates its effects on body composition, appetite modulation, cardioprotection, and its synergistic action with GHRH analogues.
02
Mechanism of Action
GHRP-2 binds to the GHS-R1a receptor and also blocks somatostatin release, removing the inhibitory brake on GH secretion. This dual action creates a potent and reliable GH secretory response. It also activates the NPY pathway, contributing to appetite stimulation.
03
Research Highlights
Phase II clinical data shows significant GH elevation for 2-3 hours post-administration
Cardiac ischemia models show cytoprotective effects and reduced cardiomyocyte apoptosis
Co-administration with GHRH analogues shows multiplicative GH pulse amplification
04
Dosage
Administration & Timing
Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue, 1–3× daily. Research protocols administer on an empty stomach (avoid food 30 min before/after) to maximize GH pulse.
Dosage Guidelines
Cycle Length
4–8 weeks; followed by 2–4 week rest.
05
Reconstitution
Solvent
Bacteriostatic Water (0.9% benzyl alcohol)
Volume
2 mL added to a 5 mg vial
Concentration
2.5 mg/mL (2,500 mcg/mL)
Storage
Refrigerate at 2–8 °C; protect from light. Discard 30 days after reconstitution.
Notes
GHRP-2 increases appetite (ghrelin-mimetic). Fast 30 minutes pre- and post-dose for optimal GH response.
Research Reference Only
Dosage and reconstitution values reflect commonly cited ranges from published research literature and are presented for educational and research reference only. This is not medical advice or a dosing recommendation. HEXAGEN does not endorse human use of any compound. Always consult a qualified healthcare professional.
Research Disclaimer
GHRP-2 is for educational and research purposes only. Not intended as medical advice. Consult a qualified healthcare professional before making any health-related decisions.
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GHRP-2 — Common Research Questions
What is GHRP-2?
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide and potent ghrelin receptor agonist. It is one of the most studied GHRPs, capable of stimulating significant GH pulses. Research ... GHRP-2 belongs to the Weight Loss research category and is studied for its growth hormone releasing peptide-2.
How does GHRP-2 work?
GHRP-2 binds to the GHS-R1a receptor and also blocks somatostatin release, removing the inhibitory brake on GH secretion. This dual action creates a potent and reliable GH secretory response. It also activates the NPY pathway, contributing to appetite stimulation.
What are the key research benefits of GHRP-2?
Potent GH pulse stimulation. Enhanced fat mobilization and metabolism. Muscle anabolism and recovery support. Appetite stimulation (via ghrelin mimicry). Cardioprotective properties in research. Sleep depth improvement.
What is the molecular structure of GHRP-2?
GHRP-2 has the molecular formula C45H55N9O6 and a molecular weight of 817.98 g/mol. Its amino acid sequence is D-Ala-D-βNal-Ala-Trp-D-Phe-Lys-NH2. This structural information is important for researchers studying receptor binding and pharmacokinetics.
What does the research say about GHRP-2?
Phase II clinical data shows significant GH elevation for 2-3 hours post-administration Cardiac ischemia models show cytoprotective effects and reduced cardiomyocyte apoptosis Co-administration with GHRH analogues shows multiplicative GH pulse amplification These findings are based on preclinical and clinical research. GHRP-2 is a research compound and these studies do not constitute medical advice.
Is GHRP-2 FDA approved?
No. GHRP-2 is not FDA-approved for any indication. It is a research chemical studied in preclinical and early clinical research. These compounds are not approved for human therapeutic use and should only be studied in appropriate research settings.
What category does GHRP-2 belong to?
GHRP-2 belongs to the Weight Loss category, which focuses on compounds studied for their roles in metabolic regulation, growth hormone signaling, and targeted adipose tissue reduction. You can explore more compounds in this category on the Weight Loss pillar page.
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Scientific References
Bowers et al. — "GHRP-2: ghrelin receptor agonist" (Endocrinology, 1999)
Cardiac ischemia cytoprotection studies, J Mol Cell Cardiol, 2010
Phase II clinical data shows significant GH elevation for 2-3 hours post-administration
Cardiac ischemia models show cytoprotective effects and reduced cardiomyocyte apoptosis
Co-administration with GHRH analogues shows multiplicative GH pulse amplification