Humanin
The Cytoprotective Mitochondrial Peptide
Molecular Data
- Formula
- C97H168N34O29S
- Molecular Weight
- 2356.7 g/mol
01
Overview
Humanin is a 21-amino-acid mitochondria-derived peptide encoded within the 16S rRNA gene of the mitochondrial genome. Originally discovered in 2001 in the context of Alzheimer's research, it has since been identified as a broad cytoprotective and anti-apoptotic peptide with roles in metabolic regulation, cardioprotection, and longevity.
02
Mechanism of Action
Humanin binds to the tri-functional receptor complex consisting of CNTFR, IL-27Rα, and gp130, activating JAK2/STAT3 signaling and promoting cell survival. It also directly inhibits BAX, a pro-apoptotic protein, and interacts with cytoplasmic IGFBP-3 to modulate IGF-1 bioavailability.
03
Research Highlights
Centenarian offspring studies show elevated circulating Humanin levels versus age-matched controls
Alzheimer's research demonstrates protection of neurons against toxic amyloid beta peptides
Metabolic studies show reduction in atherosclerotic plaque formation in hyperlipidemic mice
04
Dosage
Administration & Timing
Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue or Oral administration (capsule or solution). Research protocols use once or twice daily; timing independent of food.
Dosage Guidelines
Cycle Length
2–4 weeks; research is largely preclinical.
05
Reconstitution
Solvent
Bacteriostatic Water (0.9% benzyl alcohol)
Volume
2 mL added to a 5 mg vial
Concentration
2.5 mg/mL
Storage
Lyophilized powder: store at -20 °C long-term. Reconstituted: refrigerate 2–8 °C, use within 30 days.
Notes
Humanin is a 24-amino-acid mitochondrial peptide. Oral bioavailability is limited; SC is preferred in research.
Research Reference Only
Dosage and reconstitution values reflect commonly cited ranges from published research literature and are presented for educational and research reference only. This is not medical advice or a dosing recommendation. HEXAGEN does not endorse human use of any compound. Always consult a qualified healthcare professional.
Research Disclaimer
Humanin is for educational and research purposes only. Not intended as medical advice. Consult a qualified healthcare professional before making any health-related decisions.
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Humanin — Common Research Questions
What is Humanin?
Humanin is a 21-amino-acid mitochondria-derived peptide encoded within the 16S rRNA gene of the mitochondrial genome. Originally discovered in 2001 in the context of Alzheimer's research, it has since... Humanin belongs to the Anti Aging research category and is studied for its the cytoprotective mitochondrial peptide.
How does Humanin work?
Humanin binds to the tri-functional receptor complex consisting of CNTFR, IL-27Rα, and gp130, activating JAK2/STAT3 signaling and promoting cell survival. It also directly inhibits BAX, a pro-apoptotic protein, and interacts with cytoplasmic IGFBP-3 to modulate IGF-1 bioavailability.
What are the key research benefits of Humanin?
Neuroprotection against beta-amyloid toxicity. Anti-apoptotic signaling in multiple cell types. Insulin sensitization and metabolic benefit. Cardiovascular protection against ischemic injury. Circulating levels correlate with longevity in centenarians. Anti-inflammatory signaling through STAT3.
What is the molecular structure of Humanin?
Humanin has the molecular formula C97H168N34O29S and a molecular weight of 2356.7 g/mol. This structural information is important for researchers studying receptor binding and pharmacokinetics.
What does the research say about Humanin?
Centenarian offspring studies show elevated circulating Humanin levels versus age-matched controls Alzheimer's research demonstrates protection of neurons against toxic amyloid beta peptides Metabolic studies show reduction in atherosclerotic plaque formation in hyperlipidemic mice These findings are based on preclinical and clinical research. Humanin is a research compound and these studies do not constitute medical advice.
Is Humanin FDA approved?
No. Humanin is not FDA-approved for any indication. It is a research chemical studied in preclinical and early clinical research. These compounds are not approved for human therapeutic use and should only be studied in appropriate research settings.
What category does Humanin belong to?
Humanin belongs to the Anti Aging category, which focuses on peptides researched for their telomere-supporting, mitochondrial-protective, and senolytic properties aligned with healthy longevity science. You can explore more compounds in this category on the Anti Aging pillar page.
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Scientific References
Hashimoto et al. — Discovery and cytoprotection (Nature, 2001)
Yen & Mobbs — Centenarian offspring circulating Humanin study, 2020
Centenarian offspring studies show elevated circulating Humanin levels versus age-matched controls
Alzheimer's research demonstrates protection of neurons against toxic amyloid beta peptides
Metabolic studies show reduction in atherosclerotic plaque formation in hyperlipidemic mice