Endocrinology
GLP-1
Glucagon-Like Peptide-1 (GLP-1) is an incretin hormone that stimulates glucose-dependent insulin secretion and suppresses appetite.
Detailed Explanation
GLP-1 is released from intestinal L-cells after eating. It activates the GLP-1 receptor on pancreatic beta cells (stimulating insulin) and the brain (reducing appetite). GLP-1 receptor agonists include Semaglutide (Wegovy®/Ozempic®) and the dual GIP/GLP-1 agonist Tirzepatide. These compounds have revolutionized obesity and type 2 diabetes treatment, with weight reductions of 15-22%.