Endocrinology
Incretin
Incretins are gut hormones (GLP-1 and GIP) released after eating that amplify insulin secretion in a glucose-dependent manner.
Detailed Explanation
The incretin effect accounts for 50-70% of post-meal insulin secretion. GLP-1 and GIP are the two main incretins. Tirzepatide is a dual GIP/GLP-1 receptor agonist ("twincretin"), and Retatrutide adds glucagon receptor activity for a triple agonist approach. These incretin-based therapies represent the most effective pharmacotherapy for obesity to date.