Biology
Senescence
Cellular senescence is a state in which cells stop dividing but do not die, accumulating with age and contributing to tissue dysfunction and inflammation.
Detailed Explanation
Senescent cells secrete pro-inflammatory factors (SASP - senescence-associated secretory phenotype) that damage neighboring cells. FOXO4-DRI is a senolytic peptide that selectively induces apoptosis in senescent cells by disrupting the FOXO4-p53 interaction. Clearance of senescent cells is a leading approach in geroscience research.