Neuroscience
Neurogenesis
Neurogenesis is the process by which new neurons are formed in the brain, primarily occurring in the hippocampal dentate gyrus in adults.
Detailed Explanation
Adult neurogenesis is critical for learning, memory, and mood regulation. Peptides that promote neurogenesis include Cerebrolysin (demonstrated by BrdU incorporation in hippocampal dentate gyrus), P21 (CNTF-derived neurogenic peptide), and PE-22-28 (hippocampal neurogenesis via TREK-1 blockade). Reduced neurogenesis is associated with depression and cognitive decline.