Neuroscience
Synaptogenesis
Synaptogenesis is the formation of new synapses between neurons, essential for learning, memory, and neural circuit development.
Detailed Explanation
Dihexa is the most potent synaptogenic compound studied, demonstrating approximately 10 million times greater potency than BDNF in inducing synapse formation. It works by binding hepatocyte growth factor (HGF) and facilitating its interaction with the MET receptor, triggering dendritic spine formation. PE-22-28 also promotes synaptogenesis through BDNF-TrkB pathway activation.