Neuroscience
NGF
Nerve Growth Factor (NGF) is a neurotrophin that supports the growth, maintenance, and survival of neurons, particularly sensory and sympathetic neurons.
Detailed Explanation
NGF was discovered by Rita Levi-Montalcini and Stanley Cohen (Nobel Prize 1986). It promotes neuronal differentiation, axon guidance, and synaptic plasticity. Peptides like Semax and Noopept upregulate NGF expression in the hippocampus and cerebral cortex, contributing to their cognitive-enhancing effects. NGF decline is associated with age-related cognitive impairment.