Endocrinology
GHRH
Growth Hormone-Releasing Hormone (GHRH) is a hypothalamic peptide that stimulates the pituitary gland to release growth hormone.
Detailed Explanation
GHRH binds GHRH receptors on pituitary somatotrophs, activating the cAMP/PKA pathway to stimulate both synthesis and pulsatile release of GH. GHRH analogues include CJC-1295 (with DAC for extended half-life), Tesamorelin (FDA-approved for visceral fat reduction), and Sermorelin (bioidentical GHRH fragment 1-29). These peptides preserve the natural pulsatile pattern of GH release.